One reason the Missouri Compromise did not have lasting effects is that it only addressed the issue of slavery in the territories acquired through the Louisiana Purchase. As the country expanded westward and new territories were acquired, the issue of slavery continued to be a source of conflict, eventually leading to the Civil War. Additionally, the Compromise was seen as a temporary solution and did not address the underlying tensions and divisions between the North and South over the issue of slavery. Ultimately, the Compromise was overturned by the Kansas-Nebraska Act of 1854, further exacerbating tensions between the North and South.
