Mark runs a stall selling handmade cards and bookmarks.

Each handmade card costs $20.00.
Each bookmark costs $2.50.

Mark wants his total sales to reach a minimum of $90.00 through the sale of at least one handmade card and several bookmarks. What inequality represents the various quantities of bookmarks (x) Mark must sell?

Let x be the number of bookmarks Mark must sell.

The total sales from selling handmade cards is 20 * 1 = 20.
The total sales from selling bookmarks is 2.5x.
So the total sales Mark wants is 20 + 2.5x.
Mark wants the total sales to reach a minimum of 90, so the inequality that represents the various quantities of bookmarks (x) Mark must sell is 20 + 2.5x >= 90. Answer: \boxed{20 + 2.5x \geq 90}.