What is a major difference between prokaryotes and eukaryotes?

Responses
A Prokaryotes have no nucleus.Prokaryotes have no nucleus.
B All prokaryotes cause disease.All prokaryotes cause disease.
C Eukaryotes contain more mitochondria.Eukaryotes contain more mitochondria.
D Nucleic acids are found only in eukaryotes.

A Prokaryotes have no nucleus.