To ask if someone is from Spain in Spanish, you can say: "¿Eres de España?" or "¿Eres español?" If you want to address the person formally, you can use "Usted" instead of "Tú" and say: "¿Es usted de España?" or "¿Es usted español?" Similarly, in the plural form, you can ask, "¿Son ustedes de España?" or "¿Son ustedes españoles?"
