Hemophilia is a hereditary bleeding disorder that primarily affects males. In 3–5 sentences, summarize why this condition typically affects males more than females.(4 points)

In males (who have only one X chromosome), one altered copy of the gene in each cell is enough to cause the condition. Since females have two X chromosomes, a mutation must be present in both copies of the gene to cause the hemophilia. Males are affected by X-linked recessive disorders much more frequently than females.

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Hemophilia is a genetic disorder caused by a mutation in the genes responsible for blood clotting. The disorder is typically inherited through the X chromosome, with the faulty gene passed down from carrier females to affected males. Since males have only one X chromosome, if it carries the mutated gene, they will develop hemophilia. In contrast, females have two X chromosomes, so even if one carries the mutated gene, the other healthy X chromosome can provide a working copy of the clotting factor, reducing the severity of the disorder or eliminating symptoms entirely.