mutations are beneficial neutral or harmful in an organism changing their fitness in a population which of these scenarios model how mutations can be detrimental to an organism

1. A mutation occurs in a gene responsible for producing a crucial enzyme that is necessary for an organism to metabolize a particular type of food. This mutation leads to a non-functional enzyme, causing the organism to be unable to properly digest and obtain nutrients from that food source, resulting in decreased fitness and potentially leading to reduced reproductive success.

2. A mutation occurs in a gene responsible for controlling the growth and development of an organism's limbs. This mutation results in abnormal limb development, leading to physical disabilities that hinder the organism's ability to move, hunt, and escape from predators, ultimately reducing its overall fitness and survival chances.

3. A mutation occurs in a gene that regulates the production of a hormone crucial for coordinating the organism's responses to stress. This mutation disrupts the normal function of the hormone, causing the organism to be unable to effectively cope with stressful situations, leading to increased susceptibility to disease, impaired reproductive success, and reduced overall fitness in the population.