What was the major cause of those players in the later stages of CTE?

The major cause of Chronic Traumatic Encephalopathy (CTE) in later stages is repeated head trauma, such as concussions or subconcussive hits, often experienced by athletes in contact sports like football, hockey, and boxing. These repeated blows to the head can lead to the accumulation of abnormal protein deposits in the brain, causing neurodegenerative changes and leading to symptoms such as cognitive impairment, memory loss, mood swings, and eventually, severe neurological deficits.