A person who hasn’t smoked for two hours, and is irritable is showing symptoms of

nicotine withdrawal.

When a person stops smoking, their body goes through withdrawal symptoms due to the absence of nicotine, which is an addictive substance found in cigarettes and other tobacco products. One of the common symptoms of nicotine withdrawal is irritability, which can manifest as being easily annoyed, short-tempered, or even angry. It usually occurs within a few hours after the last cigarette and can persist for a few weeks or more, depending on the person and their smoking history. Other symptoms of nicotine withdrawal may include cravings for cigarettes, anxiety, restlessness, difficulty concentrating, increased appetite, and disturbed sleep patterns.