5/8 of the 64 musicians in a music contest are guitarists. Some of the guitarists play jazz solo, and the rest, play classical solos the ratio of the number of guitarists playing jazz solo to the total number of guitarists in the contest is 1:4. How many guitarists play classical solos in the contest?

The number of guitarists in the contest is 5/8 x 64 = <<5/8*64=40>>40.

The number of guitarists playing jazz solos is 1/1+4 x 40 = 1/5 x 40 = <<1/5*40=8>>8.
So, 40 - 8 = <<40-8=32>>32 guitarists play classical solos. Answer: \boxed{32}.