What is the one gene - one polypeptide hypothesis explain in point form
- One gene - one polypeptide hypothesis states that each gene in an organism's DNA encodes for the synthesis of one polypeptide or protein.
- It was proposed by Beadle and Tatum in 1941 based on their experiments with Neurospora crassa fungus.
- According to this hypothesis, each gene contains the information necessary to produce a specific polypeptide chain.
- These polypeptide chains, when folded correctly, form functional proteins that perform various biological functions.
- The hypothesis suggests that a change or mutation in a gene can result in the production of a defective or non-functional polypeptide, leading to genetic disorders or diseases.
- It helped explain the relationship between genes and proteins, and provided a foundation for understanding the central dogma of molecular biology.
- However, with the discovery of alternative splicing, it was later modified to the one gene - one protein hypothesis, as some genes can produce multiple proteins through different splicing patterns.