When you consume too much of this substance, your arteries begin to clog, and you increase your risk of a heart attack.

O fat
O cholesterol
O caffeine
O yogurt

The correct answer is "O fat and O cholesterol." Consuming excessive amounts of saturated and trans fats, as well as cholesterol, can lead to the build-up of plaque in your arteries, increasing the risk of a heart attack. Caffeine and yogurt do not have direct associations with artery clogging and heart attack risks.