Which of the following conditions is unaffected by physical activity?

A type 2 diabetes
B. hypertension
C. skin cancer
D. depression

C. skin cancer

Physical activity has different effects on various medical conditions. The only condition from the list that is generally unaffected by physical activity is C. skin cancer. Physical activity does not directly impact the development or progression of skin cancer. However, it is important to note that physical activity can indirectly affect skin cancer risk through its effect on overall health and well-being.