In order for a lymphocyte to respond to an antigen, the antigen must

bind to the DNA of the lymphocyte.
depolarize the lymphocyte.
be phagocytized by the lymphocyte.
bind to specific receptors on the lymphocyte membrane.
enter the cytoplasm of the lymphocyte.

bind to specific receptors on the lymphocyte membrane.

In order for a lymphocyte to respond to an antigen, the antigen must bind to specific receptors on the lymphocyte membrane. This interaction triggers a series of events that lead to the activation of the lymphocyte and its immune response. The antigen does not need to bind to the DNA or enter the cytoplasm of the lymphocyte to initiate a response. It also does not depolarize the lymphocyte or be phagocytized by the lymphocyte. The specific receptor binding is the key step in antigen recognition and lymphocyte activation.