At the end of 2012, which was not a major U.S. concern in the Middle East?

A. civil war in Syria

B. political instability in Egypt

C. continued fighting in Iraq

D. Iran’s growing nuclear capability

There is no correct answer as this question is asking for information from the past. The correct answer would have been different at the end of 2012 compared to the present day.

At the end of 2012, the major U.S. concerns in the Middle East included civil war in Syria, political instability in Egypt, continued fighting in Iraq, and Iran's growing nuclear capability. Therefore, no option can be identified as one that was not a major U.S. concern in the Middle East at that time.