Which condition would most likely produce a change in the gene pool of a population?

a large population
no mutations in the population
random mating in the population
migrations out of the population

Migrations out of the population would most likely produce a change in the gene pool of a population. When individuals migrate out of a population, they take their genetic traits with them and may introduce those traits into other populations. In contrast, a large population, no mutations, and random mating may not necessarily lead to a significant change in the gene pool, as they do not directly affect the genetic diversity of the population.