A DNA said we has bass order AGC TTA TCA Which copy exhibits a frameshift mutation Through deletion?
To identify which copy of the DNA sequence exhibits a frameshift mutation through deletion, we need to first understand what frameshift mutations are and how they occur.
A frameshift mutation is a type of genetic mutation that causes a disruption in the normal reading frame of a DNA sequence. It occurs when nucleotides (genetic code letters) are added or deleted, shifting the codon reading frame by a number other than a multiple of three. This shift in reading frame can potentially alter the entire sequence of amino acids produced during translation, leading to a non-functional or impaired protein.
Now, let's analyze the given DNA sequence: AGC TTA TCA.
To determine which copy exhibits a frameshift mutation through deletion, we can try deleting one or more nucleotides and observe the resulting sequences to see if any frameshifts occur.
Let's examine the possibilities:
1. Deleting the first nucleotide (A): GC TTA TCA.
After the deletion, the reading frame remains intact (no shift by a non-multiple of three). Therefore, this deletion does not cause a frameshift mutation.
2. Deleting the second nucleotide (G): AC TTA TCA.
Again, after the deletion, the reading frame remains intact. So, this deletion does not cause a frameshift mutation.
3. Deleting the third nucleotide (C): AG TTA TCA.
Once again, after the deletion, there is no shift by a non-multiple of three. Therefore, this deletion does not cause a frameshift mutation.
4. Deleting the fourth nucleotide (T): AGC TA TCA.
This deletion causes a frameshift mutation, as the entire reading frame is shifted by one nucleotide. From this point forward, every codon will be different in the translated protein.
5. Deleting the fifth nucleotide (T): AGC TT ACA.
This deletion also causes a frameshift mutation, as the reading frame is shifted by one nucleotide. All subsequent codons will be altered.
6. Deleting the sixth nucleotide (A): AGC TTA CA.
Similarly, this deletion leads to a frameshift mutation, shifting the reading frame by one nucleotide.
7. Deleting the seventh nucleotide (T): AGC TTA TC.
Again, this deletion causes a frameshift mutation, with a shift of one nucleotide.
From the above analysis, we can conclude that the copies exhibiting a frameshift mutation through deletion are:
- Copy 4: AGC TA TCA
- Copy 5: AGC TT ACA
- Copy 6: AGC TTA CA
- Copy 7: AGC TTA TC
These copies have deletions of one nucleotide, resulting in a frameshift mutation.