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Mefenamic acid (Ponstan Forte) has a half life of 2 hours.

Naproxen has a half life of 12 to 17 hours.

Both are anti inflammatory drugs of apparently similar nature but could someone please explain the difference in half life?

Thank you


  • Chemistry -

    Absorbtion and breakdown are enzymatic reactions in the liver, "similar" is not good enough for many enzymes in reaction energy or speed. I would bet different enzyme pathways on breakdown.

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