posted by Mike .
Mefenamic acid (Ponstan Forte) has a half life of 2 hours.
Naproxen has a half life of 12 to 17 hours.
Both are anti inflammatory drugs of apparently similar nature but could someone please explain the difference in half life?
Absorbtion and breakdown are enzymatic reactions in the liver, "similar" is not good enough for many enzymes in reaction energy or speed. I would bet different enzyme pathways on breakdown.