Use the passage to answer the question.

The level of insulin in the blood is regulated by negative feedback. Which observation MOST supports this model?

Insulin secretion increases metabolic syndrome symptoms

Insulin secretion decreases metabolic syndrome symptoms.

insulin receptor pnosprioryiation increases insulin secretion.

Insulin receptor phosphorylation decreases insulin secretion.

A)

(1 point)

Metabolic Syndrome

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100

Metabolic syndrome is a clustering of various conditions including high blood pressure, high blood sugar excess body fat, high serum triglycerides, and low high-density lipoproteins. Scientists studying metabolic syndrome cultured fibroblast cells from a metabolic syndrome patient and a healthy volunteer and challenged the cells to 100 nM insulin. Ten minutes after the stimulus was applied, they used a protein Immunoblot to measure the amount of phosphorylated insulin receptor in the cultures.

Healthy

100

0

Insulin (nM) Insulin Receptor

Phosphorylated Insulin Receptor

Insulin secretion decreases metabolic syndrome symptoms. This observation of insulin receptor phosphorylation decreasing insulin secretion aligns with the idea of negative feedback regulation of insulin levels in the blood.