Simplify the radical expression (5+√3)(5-√3)

To simplify the given expression, we will use the formula for the product of two conjugate binomials:

(a + b)(a - b) = a^2 - b^2

In this case, a = 5 and b = √3:

(5 + √3)(5 - √3) = 5^2 - (√3)^2
= 25 - 3
= 22

Therefore, the simplified form of the expression (5 + √3)(5 - √3) is 22.