Out of My Mind is told from the Point of View of an 11-year-old girl, named Melody Brooks. Melody was born with cerebral palsy, meaning she is unable to walk, talk, feed herself, or take care of herself. Their next-door neighbor Valencia, or Mrs. V, is her part-time caregiver. Melody is very intelligent, she has a photographic memory and can take in everything she hears or sees. While music is playing, Melody finds out she can hear colors and smell images. However, Melody wishes she was able to live and\ communicate like every other kid.

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The story of Out of My Mind is narrated by an 11-year-old girl named Melody Brooks, who has cerebral palsy and relies on her neighbor Mrs. V for assistance. Despite her physical limitations, Melody possesses exceptional intelligence, with a photographic memory that allows her to absorb information effortlessly. She discovers the ability to hear colors and smell images while music plays. However, Melody longs to be able to live and communicate like her peers.