Which of the following species would have the greatest chance of going extinct

1. A widespread species with a large population size

2. An endemic species with a small population size
3. A species with a high reproductive rate
4. A species with a low reproductive rate

The endemic species with a small population size would have the greatest chance of going extinct. This is because small populations are more vulnerable to environmental changes, diseases, and other threats, and their limited genetic diversity can make it difficult for them to adapt to changing conditions.