And a large right ventricle both increases oxygen intake and the risk of pulmonary hypertension how can natural selection result in adaption that produces both positive and negative effects

Natural selection is the process by which certain traits that increase an organism's chances of survival and reproduction become more common in a population over time. In the case of a large right ventricle that increases oxygen intake, individuals with this trait may have an advantage in environments with low oxygen levels, such as high altitudes. This trait would allow them to extract more oxygen from the air and potentially outcompete individuals with smaller right ventricles.

However, a large right ventricle also increases the risk of pulmonary hypertension, a condition that can be harmful to an individual's health. In this case, natural selection may favor individuals with a slightly smaller right ventricle that can still provide enough oxygen intake without the negative effects of pulmonary hypertension. Over time, individuals with this more balanced trait would be more likely to survive and reproduce, leading to the evolution of a trait that provides the benefits of increased oxygen intake without the drawbacks of pulmonary hypertension.

In this way, natural selection can result in the adaptation of traits that have both positive and negative effects, as long as the overall benefits outweigh the costs. The balance between these effects is constantly shifting in response to changes in the environment and the selective pressures acting on the population.