The Pythagorean Theorem can be used to find the distance between two points on the coordinate plane by treating the coordinates of the two points as the lengths of the legs of a right triangle. By calculating the difference in the x-coordinates and the difference in the y-coordinates of the two points, these values can be plugged into the Pythagorean theorem formula (a^2 + b^2 = c^2) to find the distance between the two points.
