Which of the following are accurate statements about how Europe changed as a result of Otto the great’s rule?

1. Otto the Great expanded the power and influence of the Holy Roman Empire.

2. Otto the Great strengthened the centralized authority of the German monarchy.
3. Otto the Great helped establish the concept of a unified Christian Europe under the Holy Roman Empire.
4. Otto the Great's rule laid the foundation for future conflicts between the Holy Roman Empire and the Papacy.

All of the above statements are accurate in describing how Europe changed as a result of Otto the Great's rule.