The main difference between a pandemic and an epidemic is:

A. an epidemic must be infectious
B. a pandemic must be infectious
C. epidemics are at a much larger scale
D. none of the above

B. a pandemic must be infectious

An epidemic is an outbreak of a disease that affects a large number of people within a community, population, or region. A pandemic, on the other hand, is an epidemic that has spread across multiple countries or continents and affects a large number of people worldwide. Pandemics are typically infectious diseases, but epidemics can also refer to non-infectious health issues such as obesity or substance abuse.