Which mutation scenario will always lead To natural selection?

Any mutation scenario that results in a change to an organism's phenotype that affects its survival and reproduction in its environment will likely lead to natural selection. This is because natural selection is the process by which certain traits are favored or selected for, leading to their increased prevalence in a population over time. If a mutation results in a beneficial trait that helps an organism survive and reproduce, it is more likely to be passed on to future generations through natural selection. Conversely, if a mutation results in a harmful trait that decreases an organism's ability to survive and reproduce, it is less likely to be passed on through natural selection.