what does pestilence mean as it is using the following lines from AV scene two of Romeo and Juliet

Friar John; going to find a barefoot, brother out, one out of our order, to associate me, here, in the city, visiting the sick, and finding him, the searchers of the town, suspecting that we both were in the house, where the infectious is pestilence did reign, seal’d up the doors, and would not let us forth; so that my speed to mantua there was stay’d

Danger

Enemy

Plague

Thoughts

Pestilence in this context refers to a plague or infectious disease that was spreading in the city.