Summarise in your own words:

One of the most pivotal issues motivating the need for global governance of heritable genome editing, is the necessity of avoiding premature ventures into human applications. When considering the safety of any editing of the human genome, the Draft Framework notes that all medical interventions carry a risk to individuals. The question then becomes ‘what is safe enough?’ In most instances the impact of medical interventions affects only the individual undergoing such intervention, although there are many instances of medication having unwanted effects on future generations (eg, thalidomide).

The need for global governance of heritable genome editing is driven by the importance of preventing premature experimentation on humans. The Draft Framework acknowledges that all medical interventions carry risks, leading to the question of what level of safety is acceptable. While most medical interventions only affect the individual receiving treatment, there have been cases where medication has had unintended consequences for future generations.