Distribution of histamine
Widely distributed in:- bacteria, plants, animals and
venoms and stinging fluids (stinging nettle, insect
stings, bee venom).
Either stored or quickly inactivated (metabolism) by
histamine-N-methyltransferase (methylation) and
diamine oxidase (deamination) in the small intestine,
liver, kidney and skin.
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In humans, histamine is mainly found in mast cells and basophils in various tissues such as skin, lungs, and gastrointestinal tract.
It is also present in certain foods such as aged cheese, fermented foods, and alcoholic beverages.
Histamine plays a key role in allergic reactions, inflammation, and regulation of stomach acid production.
Imbalance in histamine levels can lead to various health issues such as allergies, asthma, and digestive disorders.