Which of the following BEST describes how the Spanish and Hernando DeSoto impacted the Native Americans living in the southeastern region of North America? A. Native Americans benefitted from learning about new technologies from the Europeans. B. They formed a strong alliance and became trading partners. C. The Native Americans were introduced to new foods. D. Thousands of Native Americans died as a result of diseases spread by contact with Europeans.

what is the correct option out of them all?

D. Thousands of Native Americans died as a result of diseases spread by contact with Europeans.

that is correct 110% right?

Yes, the correct option is D. Thousands of Native Americans died as a result of diseases spread by contact with Europeans. This statement accurately describes the devastating impact of European colonization on Native American populations in the southeastern region of North America.