It is difficult to give an exact percentage as immunity can come from various sources such as vaccination, previous infection, or a combination of both. However, as of October 2021, approximately 57% of the U.S. population is fully vaccinated against COVID-19 according to the Centers for Disease Control and Prevention (CDC). Additionally, there have been millions of confirmed COVID-19 cases in the U.S., so a significant portion of the population likely has some level of immunity from previous infection.