adverse effect of bethanicol and neostigmine difference
Bethanechol and neostigmine are both cholinergic drugs that activate the parasympathetic nervous system. However, they differ in their mechanism of action and potential adverse effects.
Bethanechol works by directly stimulating muscarinic receptors, leading to increased smooth muscle contractions in the gastrointestinal tract and urinary bladder. Common adverse effects of bethanechol include abdominal cramps, diarrhea, and excessive salivation.
Neostigmine, on the other hand, works by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine and thus prolonging the action of acetylcholine at the neuromuscular junction. Common adverse effects of neostigmine include bradycardia, increased bronchial secretions, and muscle weakness.
Both drugs can also cause cholinergic side effects such as sweating, flushing, nausea, and blurred vision. It is important to monitor patients closely for these adverse effects and adjust the dosage as needed to minimize the risk of complications.