Subtract the mixed numbers 5 3/8 and 2 1/2.

To subtract 2 1/2 from 5 3/8, we first need to convert both mixed numbers to improper fractions.

5 3/8 = (8 * 5 + 3)/8 = 43/8
2 1/2 = (2 * 2 + 1)/2 = 5/2

Now, we can subtract the fractions:

43/8 - 5/2 = (43/8) - (20/8) = 23/8

Now, we need to convert the improper fraction back to a mixed number:

23/8 = 2 7/8

Therefore, the result of subtracting 2 1/2 from 5 3/8 is 2 7/8.