What is the primary question surrounding the 1832 Nullification Crisis?

Can the federal government regulate interstate commerce
Can a state regulate interstate commerce

The primary question surrounding the 1832 Nullification Crisis was whether a state had the authority to nullify, or reject, a federal law within its own borders if the state believed that law was unconstitutional. The crisis specifically revolved around the issue of tariffs, which many southern states believed were unfairly burdening their economies. South Carolina, in particular, argued that it had the right to nullify the tariffs within its state borders, while the federal government insisted on its authority to regulate interstate commerce, including the imposition of tariffs.