Of the following, which calculation comes first in the order of operations?

A.
Multiplication

B.
Parentheses

C.
Division

D.
Subtraction

The order of operations is typically represented by the acronym "PEMDAS" or "Please Excuse My Dear Aunt Sally," which stands for Parentheses, Exponents, Multiplication and Division (from left to right), and Addition and Subtraction (from left to right). Therefore, B (Parentheses) comes first in the order of operations.