How did American settlement in the Oregon country change starting in the 1840s

a if you were settlers, came as the California gold rush through most settlers
B as the British establish control over the region fewer Americans came
C disease in conflict with Native Americans made settlement more difficult
D missionaries and settlers join the trainers there in earlier years

The correct answer is C. Disease and conflict with Native Americans made settlement more difficult in the Oregon country starting in the 1840s.

In the 1840s, American settlement in the Oregon country faced numerous challenges. One significant factor was the outbreak of diseases, such as smallpox and measles, brought by the settlers. These diseases severely impacted Native American communities, leading to a decline in their population and subsequent conflicts with the settlers.

Additionally, conflicts between Native Americans and the settlers erupted due to the increased influx of American settlers into the region. These conflicts made it more difficult for settlers to establish a stable presence and expand their settlements.

Overall, these disease outbreaks and conflicts with Native Americans posed significant challenges to American settlement in the Oregon country in the 1840s and altered the dynamics of the region.