Which of the following BEST describes how the Spanish and Hernando DeSoto impacted the Native Americans living in the southeastern region of North America?

A. Native Americans benefitted from learning about new technologies from the
Europeans.

B. They formed a strong alliance and became trading partners.

C. The Native Americans were introduced to new foods.

D. Thousands of Native Americans died as a result of diseases spread by
contact with Europeans.

D. Thousands of Native Americans died as a result of diseases spread by contact with Europeans.