To stop a wound from bleeding, platelets in the blood clump together to form a blood clot. The clot dries into a hard scab to protect the wounded area. Underneath the scab, the blood supplies nutrients and oxygen that help new skin cells form. As the skin regenerates, the wound closes.

Which body systems interact with the integumentary system to close the wound?
A Circulatory and reproductive
® Immune and circulatory
© Reproductive and immune
Digestive and endocrine

The correct answer is the immune and circulatory systems. The immune system helps to prevent infection in the wound and promotes healing, while the circulatory system supplies the necessary nutrients and oxygen to the area for new skin cell formation. The digestive and endocrine systems do not directly interact with the integumentary system in wound healing, and the reproductive system is not directly involved in this process either.