Why is the case of Marbury v. Madison significant?

It was the last time that the U.S. Supreme Court ruled a law unconstitutional.
It was the case that ended segregation in the United States.
It was the case that started segregation in the United States.
It was the first time that the U.S. Supreme Court ruled a law unconstitutional.

The correct answer is: It was the first time that the U.S. Supreme Court ruled a law unconstitutional.

Marbury v. Madison is significant because it established the principle of judicial review, which is the power of the Supreme Court to determine the constitutionality of laws. This landmark decision in 1803 solidified the Court's role as the ultimate arbiter of the Constitution and has had a lasting impact on American constitutional law.