An analysis of the long-term impacts of the Columbian Exchange on Indigenous North American populations would show that(1 point) Responses Indigenous groups resisted European invasion of their homelands. Indigenous groups resisted European invasion of their homelands. Old World goods became widely accessible to Indigenous populations. Old World goods became widely accessible to Indigenous populations. Indigenous cultures faced the threat of extinction. Indigenous cultures faced the threat of extinction. productive and thriving trade agreements were formed.

Indigenous cultures faced the threat of extinction.