Which of the following BEST describes how the Spanish and Hernando DeSoto impacted the Native Americans living in the southeastern region of North America?

A.
Native Americans benefitted from learning about new technologies from the Europeans.
B.
They formed a strong alliance and became trading partners.
C.
The Native Americans were introduced to new foods.
D.
Thousands of Native Americans died as a result of diseases spread by contact with Europeans

D. Thousands of Native Americans died as a result of diseases spread by contact with Europeans

is the answer A

No, the answer is D. Thousands of Native Americans died as a result of diseases spread by contact with Europeans.

you sure

I apologize for any confusion. It is true that Native Americans were impacted by new technologies brought by the Europeans and that they were introduced to new foods. However, the most significant and devastating impact on the Native Americans in the southeastern region of North America was the spread of diseases. Hernando DeSoto's expedition and subsequent interactions with Native Americans led to the spread of diseases, such as smallpox, for which the Native Americans had no immunity, resulting in the deaths of thousands of Native Americans. Therefore, the correct answer is D. Thousands of Native Americans died as a result of diseases spread by contact with Europeans.