Trisomy 21 is a genetic disorder that occurs when a patient has three copies of chromosome 21 in each cell. Which mutation would MOST likely result in a similar phenotype as trisomy 21?

Question

Trisomy 21 is a genetic disorder that occurs when a patient has three copies of chromosome 21 in each cell. Which mutation would MOST likely result in a similar phenotype as trisomy 21?

inversion of the distal portion of chromosome 21

duplication of the distal portion of chromosome 21

insertion of the distal portion of chromosome 21 to chromosome 5

translocation of the distal portion of chromosome 21 to chromosome 5

Answer 1

Trisomy 21 is caused by having three copies of chromosome 21, so a similar phenotype would most likely result from a duplication of the distal portion of chromosome 21.