Cells can use endocytosis to reduce the response to extracellular signaling. Which of these BEST explains how endocytosis can reduce signal transduction? Internalization of the membrane reduces the number of receptors on the membrane, internalization of signaling molecules reduces their affinity for membrane receptors, internalization of salts increases the function of membrane transporters, or internalization of the extracellular medium increases cell size.

The BEST explanation is that internalization of the membrane reduces the number of receptors on the membrane.