Glucose can be transported into cells with a glucose/sodium symporter. If the extracellular concentration of sodium is always in excess to that of glucose, which of these manipulations would MOST increase the rate of glucose transport into a cell? A diagram shows a shape with finger-like structures on it. On the ends of some of the structures are openings labeled S G L T 2. A glucose molecule and upper N a superscript plus baseline are shown entering one of the openings labeled S G L T 2. Increase in the extracellular concentration of sodium, increase in the intracellular concentration of sodium, increase in the extracellular concentration of glucose, or increase in the intracellular concentration of glucose.

The most effective manipulation to increase the rate of glucose transport into a cell would be to increase the extracellular concentration of glucose. This would create a greater concentration gradient for glucose across the cell membrane and drive more glucose molecules into the cell through the glucose/sodium symporter.