All the gummy machines at a candy factory work at the same rate. Six machines working simultaneously can complete a big order in 22 hours.

How many hours would it take to finish the order if the number of working machines decreased by a factor of 2?

If six machines working simultaneously can complete a big order in 22 hours, then the rate of work for each machine is 1/ (6*22) = 1/132 of the order per hour.

If the number of working machines decreases by a factor of 2, then there will be 6/2 = <<6/2=3>>3 machines working.
The new rate of work for each machine would be 1/ (3*22) = 1/66 of the order per hour.
Since the number of machines has decreased by a factor of 2, the time it would take to finish the order would double. Therefore, it would take 22*2 = <<22*2=44>>44 hours to finish the order. Answer: \boxed{44}.