The following item is an artifact:

○ A knife made by early humans
○ A large bone discovered near an ancient campsite
○ A plant once used to help cure headaches

All of the above items can be considered artifacts, as they are objects or substances that have historical or cultural significance. The knife made by early humans and the large bone discovered near an ancient campsite are physical objects created or used by past human civilizations. These objects provide a window into the technology, lifestyle, and activities of early humans.

The plant once used to help cure headaches is also an artifact, although it is not a physical object. It is a natural substance that was utilized by people in the past for its medicinal properties. This artifact represents the knowledge and practices of earlier societies in treating ailments and provides insights into their understanding of medicine and healing.