Identify the scenario that could potentially result in new combinations of DNA in the offspring of the individual.

A pair of homologous chromosomes and a sperm cells failed to separate during meiosis
UV radiation causes a mutation in a skin cell resulting in melanoma
A spontaneous mutation to DNA replication in a lung cells during mitosis
Sister chromatids cross over during mitosis in a heart cell

Sister chromatids cross over during meiosis in a heart cell