In Graves' disease, the thyrotoxic symptoms typically occur before the goiter swelling. Thyrotoxic symptoms can include increased heart rate, palpitations, sweating, weight loss, tremors, anxiety, and heat intolerance. On the other hand, goiter swelling refers to the enlargement of the thyroid gland, which may be visible or palpable as a result of the increased production of thyroid hormones. The timing interval between the development of thyrotoxic symptoms and goiter swelling can vary, but it is generally within a few weeks to months. However, it's important to note that the presentation and progression of Graves' disease can vary among individuals.
