Which is one negative consequence of the Spanish colonization of Middle America?

New diseases were brought to Middle America

New foods were brought to Middle America.

New ideas from the Enlightenment were brought to Middle America.

New animals were brought to Middle America.

One negative consequence of the Spanish colonization of Middle America is that new diseases were brought to the region. These diseases, such as smallpox, measles, and influenza, were introduced by the European colonizers and decimated the indigenous populations of Middle America, leading to a significant decline in their numbers. This resulted in the loss of cultural knowledge, social structures, and traditional ways of life among the indigenous peoples.