Skylar is trying to pick out an outfit for the first day of school. She can choose from 4 pairs of pants, 2 t-shirts, 5 sweaters or hoodies, and 3 pairs of shoes. How many different outfits does Skylar have to choose from?

Skylar has 4 choices for pants, 2 choices for t-shirts, 5 choices for sweaters or hoodies, and 3 choices for shoes. To calculate the number of different outfits Skylar has to choose from, we multiply the number of choices for each category: 4 choices for pants * 2 choices for t-shirts * 5 choices for sweaters or hoodies * 3 choices for shoes = <<4*2*5*3=120>>120 different outfits. Answer: \boxed{120}.